ANTIMETABOLITE ACTIVITY OF URIDINE AND CYTIDINE DERIVATIVES
نویسندگان
چکیده
منابع مشابه
Antimetabolite Activity of Uridine and Cytidine
With the realization in 1940 (1) that structural analogues of a metabolite frequently prevent utilization of that metabolite, it became possible to develop antimetabolites which block specific biosynthetic pathways. By blocking various steps in a biosynthetic pathway, antimetabolites are useful for elucidating intermediary metabolism. It was the object of the present study to investigate the bi...
متن کاملPhosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.
Uridine-cytidine kinases (UCK) have important roles for the phosphorylation of nucleoside analogs that are being investigated for possible use in chemotherapy of cancer. We have cloned the cDNA of two human UCKs. The approximately 30-kDa proteins, named UCK1 and UCK2, were expressed in Escherichia coli and shown to catalyze the phosphorylation of Urd and Cyd. The enzymes did not phosphorylate d...
متن کاملPhosphorylation of Uridine and Cytidine Nucleoside Analogs by Two Human Uridine-Cytidine Kinases
Uridine-cytidine kinases (UCK) have important roles for the phosphorylation of nucleoside analogs that are being investigated for possible use in chemotherapy of cancer. We have cloned the cDNA of two human UCKs. The '30-kDa proteins, named UCK1 and UCK2, were expressed in Escherichia coli and shown to catalyze the phosphorylation of Urd and Cyd. The enzymes did not phosphorylate deoxyribonucle...
متن کاملMetabolism of cytidine and uridine in bean leaves.
The metabolism of cytidine-2-(14)C and uridine-2-(14)C was studied in discs cut from leaflets of bean plants (Phaseolus vulgaris L.). Cytidine was degraded to carbon dioxide and incorporated into RNA at about the same rates as was uridine. Both nucleosides were converted into the same soluble nucleotides, principally uridine diphosphate glucose, suggesting that cytidine was rapidly deaminated t...
متن کاملUridine - 5 ’ - Pyrophosphate Derivatives
The first evidence for the existence of uridine diphosphate compounds was limited to the observation that Staphylococcus aureus cells, when grown in the presence of penicillin, accumulated a new form of acid-labile phosphate in their internal environment (1). The labile phosphate appeared to be part of a complex compound which also contained uracil. In a brief note (2), it has since been report...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1952
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)55823-3